1.
BMJ Case Rep
; 14(10)2021 Oct 19.
Article
in English
| MEDLINE | ID: covidwho-1476413
ABSTRACT
We describe the case of a 45-year-old man affected by T-cell acute lymphoblastic leukaemia and diagnosed with COVID-19 early after an allogeneic haematopoietic stem cell transplant. The infectious disease was characterised by a severe and prolonged course, further complicated by a spontaneous pneumomediastinum and pneumopericardium. We successfully treated this patient with the antiviral drug remdesivir associated with two courses of COVID-19 convalescent plasma. This case report represents a good example of the typical clinical course of COVID-19 in severely immunosuppressed patients and gives evidence that in this population only a prompt treatment directed towards viral clearance can face the absence of a valid immune reactivity.
Subject(s)
COVID-19 , Coronavirus Infections , Hematopoietic Stem Cell Transplantation , COVID-19/therapy , Hematopoietic Stem Cell Transplantation/adverse effects , Humans , Immunization, Passive , Male , Middle Aged , SARS-CoV-2 , COVID-19 Serotherapy
2.
Bone Marrow Transplant
; 56(9): 2312-2315, 2021 09.
Article
in English
| MEDLINE | ID: covidwho-1291044